Statistician – Rare Diseases (Ophthalmology Focus)

• RECRUITMENT AGENCIES - PLEASE READ THE RECRUITMENT POLICY AT THE BOTTOM OF THIS ADVERT • The Company AAVantgarde is a clinical-stage, international biotechnology company headquartered in Italy. We have developed two cutting-edge AAV vector platforms to overcome DNA cargo limitations, targeting Usher syndrome type 1B and Stargardt disease. Founded by the renowned Professor Alberto Auricchio, a pioneer in gene therapy, our mission is to transform genetic medicine for patients with no current therapeutic options. Join us at AAVantgarde and be a part of our innovative journey to bring the next generation of genetic medicines to those in need. The Role We are seeking a highly skilled Statistician to support the design, analysis, and reporting of clinical trials in rare diseases, with a particular focus on ophthalmology. This role combines deep statistical expertise with hands-on programming and data analysis, contributing directly to the success of our clinical development and regulatory submissions. You will provide statistical leadership across studies, working closely with cross-functional teams to ensure the integrity and robustness of clinical trial data. From drafting statistical analysis plans to generating outputs for study reports and regulatory filings, you will be involved in every stage of the statistical lifecycle. Your input will be key in shaping study design decisions, including sample size calculations, endpoint strategies, and analysis methodologies. You will also represent the statistics function in project teams, support regulatory interactions, and contribute to internal standards and methodological innovation. This is a role for someone who enjoys both strategic thinking and technical execution, and who thrives in a collaborative, fast-paced environment. Skills and Experience Required To succeed in this role, you will need a strong foundation in statistics, ideally with an MSc or PhD in Statistics, Biostatistics, or a related discipline. You should bring 5 to 10 years of experience in clinical trial statistics within the biotech, pharmaceutical, or CRO sectors, and have a proven track record of hands-on programming using SAS and/or R. Experience in rare-disease trials is essential, and familiarity with ophthalmology studies is strongly preferred. You should have contributed to regulatory submissions and possess a solid understanding of clinical trial design, longitudinal data analysis, and regulatory expectations. The ideal candidate will be detail-oriented, rigorous, and capable of communicating complex statistical concepts clearly to non-specialist audiences. You should also be comfortable mentoring junior statisticians and balancing innovative approaches with regulatory acceptability. Equal Opportunities At AAVantgarde, we are committed to fostering a welcoming, collaborative, and inclusive environment. We believe in providing equal opportunities for all and do not discriminate on the basis of race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or any other legally protected characteristics. All applicants will receive equal consideration for employment. Recruitment Policy AAVantgarde’s HR team leads all recruitment activities for AAVantgarde globally. AAVantgarde will not recognise any notional ownership recruitment companies claim to hold over candidates they present directly to hiring managers without the AAVantgarde HR team’s consent, nor any fees the recruitment company may feel are due as a result of this. Unsolicited resumes sent to AAVantgarde from recruiters do not constitute any type of relationship between the recruiter and AAVantgarde and do not obligate AAVantgarde to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring managers or employees. If you are interested in becoming a recruitment partner please email the HR team at recruitment@aavantgarde.com