Computational Scientist II

The Opportunity At Genentech's Developmental Sciences DevSci organization we are transforming how quantitative drug development is conducted through the integration of AI and agentic workflows. Our Clinical Pharmacology and Pharmacometrics CPP group is at the forefront of this effort embedding large language model LLM-powered tools directly into pharmacometric workflows to accelerate scientific planning analysis and decision-making. We are seeking a Computational Scientist to help design build and deploy these agentic systems. You will work at the interface of AI engineering and quantitative pharmacology partnering closely with MS Scientists and Clinical Pharmacologists to develop tools that are scientifically grounded reliable and impactful. Your contributions will help CPP scale its capabilities and free scientists to focus on higher-value work - ultimately accelerating the delivery of effective therapies to patients. In This Role You Will Build and Deploy Agentic LLM Workflows - Design and implement LLM agent-based pipelines that automate or augment complex scientific workflows within the CPP group. - Develop human-in-the-loop systems that allow scientists to collaborate with AI tools through natural language iterative feedback and structured outputs. - Integrate domain-specific context - such as internal guidelines templates and scientific reference materials - into LLM workflows to ensure outputs meet scientific and regulatory standards. - Package reusable LLM workflow components and libraries and ensure tools are production-ready well-documented and accessible to scientist users with varying technical backgrounds. Develop Quality and Evaluation Infrastructure - Build automated quality control layers to evaluate LLM outputs against structural scientific and consistency criteria. - Design evaluation frameworks to measure output quality efficiency gains and failure modes over time. - Maintain versioned evaluation logs and contribute to periodic reports supporting tool improvement and stakeholder communication. Collaborate and Innovate - Work closely with pharmacometricians data scientists and automation engineers to understand scientific requirements and translate them into robust system designs. - Stay current with advances in LLM tooling agentic frameworks and AI applications in drug development and RD. - Contribute to the broader DevSci AI adoption by sharing learnings and best practices across functions as well as providing trainings. Who You Are Education You hold or are pursuing a Master's or PhD degree in a quantitative or computational field such as Computer Science Data Science Bioinformatics Computational Biology Pharmaceutical Sciences or a related discipline.OR BA/BS w/ 5 years min exp Domain Knowledge Familiarity with the drug development or pharmaceutical RD context is strongly preferred. Candidates with an awareness of clinical development processes quantitative sciences or life sciences research - and a genuine interest in applying AI to advance drug development - will thrive in this role. Software and AI/LLM Engineering Solid software engineering experience and familiarity with standard development practices - version control Git code review documentation and working effectively within collaborative codebases are expected. Comfortable working with structured and unstructured data and able to pick up new tools and frameworks quickly. Prior exposure to LLM applications is a big plus - whether through building and deploying LLM-powered pipelines working with agentic frameworks such as LangSmith retrieval-augmented generation RAG architectures harness engineering or guardrail design or integrating LLM APIs into functional tools. Familiarity with cloud platforms AWS GCP or Azure and a portfolio of relevant projects are also welcomed. Ways of Working - Collaborative and communicative - able to bridge engineering and scientific perspectives and explain technical decisions clearly. - Self-directed and ownership-oriented with a track record of delivering in ambiguous or evolving project environments. - Curious and motivated by the intersection of AI technology and real-world scientific impact. Why This Role This is a meaningful opportunity to shape how AI is applied to one of the most knowledge-intensive processes in drug development. You'll have real ownership over the tools you build and direct collaboration with the scientists who rely on them - contributing to greater efficiency consistency and scientific quality across the CPP group and beyond. Onsite position Interview process: 1. phone 2. IN-person Half day Full-time employees are also eligible for benefits options such as health coverage, life insurance, disability insurance, and 401k benefits. At Advanced Group, our commitment to diversity and inclusion in every part of our organization is crucial to fulfilling our mission and demonstrating our REAL values. Advanced Group is committed to providing employment opportunities without regard to sex, race, color, age, national origin, religion, gender identity or expression, sexual orientation or sexual preference, pregnancy or maternity, genetic information, marital status, disability, veteran status, or any other basis protected by applicable federal, state or local law. Advanced Group complies with federal and state disability laws and makes reasonable accommodations for applicants and candidates with disabilities. If a reasonable accommodation is needed to participate in the job application or interview process, please contact accommodationrequest@advancedgroup.com. #msptalent