Scientist I, Oligonucleotide Analytics

Job Title: Scientist I, Oligonucleotide Analytics Location: La Jolla, CA About the Role We are seeking a highly motivated Scientist I with expertise in oligonucleotide analytics to join our dynamic team. This is a 100% onsite role, and candidates must be able to commute daily. The ideal candidate will bring a strong background in analytical chemistry, LC-MS techniques, and hands-on experience working with siRNA, ASO, and gene therapy applications. Key Responsibilities • 30% – Operate LC-MS systems (Thermo LTQ, Thermo Orbitrap) for in-process and final QC of modified oligonucleotides (siRNA, ASO). • 20% – Optimize analytical methods and capabilities for novel oligonucleotide synthesis. • 10% – Tailor methods for specific projects (e.g., GalNAc, Cholesterol, C16 conjugates) using denaturing/non-denaturing HPLC and LC-MS. • 20% – Establish and automate high-throughput analytical capabilities in alignment with synthesis scale-up. • 5% – Analyze oligonucleotides using HPLC-SEC, RP-IP, and Ion-Exchange Chromatography. • 3% – Perform QC of lipid nanoparticle (LNP) formulations for mRNA. • 5% – Manage lab supply inventory to ensure uninterrupted operations. • 2% – Present data and reports in individual, group, and department meetings. • Collaborate with biology teams to support assay development and confirm analyte integrity (e.g., concentration checks). • Apply advanced analytical techniques and novel column matrices for optimal siRNA characterization. Qualifications • Ph.D. in Chemistry, Biochemistry, or a related field. • 1–3 years of relevant industry experience in analytical chemistry and oligonucleotide analysis. • Proven experience with: • LC-MS instrumentation (Thermo LTQ, Thermo Orbitrap LC/MS) • siRNA, ASO, and gene therapy applications • Chromatographic techniques (HPLC-SEC, RP-IP, IEX) • Familiarity with high-throughput analytical environments and method development/optimization. • Strong organizational, communication, and data presentation skills. Top 3 Required Skills 1. Expertise in LC-MS Operation 1. Method Development and Optimization 1. Automation of High-Throughput Analytical Workflows